Citation Information :
Abuji K, Gautam A, Thumma MK, Bhadada SK, Dahiya D. Giant Cell Epulis as a Presenting Manifestation of Primary Hyperparathyroidism: A Case Series from a Tertiary Care Center. 2024; 19 (1):9-12.
Brown tumors are sequelae of abnormal bone metabolism in primary hyperparathyroidism (PHPT) when there is increase in osteoclastic activity and fibroblastic proliferation. They can be located in any part of the skeleton, but commonly affect the bony thorax (ribs and clavicle), pelvic rim, and long bones (tibia and femur). Clinically, significant lesions in the craniofacial bones are rare and usually involve the mandible. Oral manifestation may be the only presenting feature of PHPT and patient generally report first to a maxillofacial surgeon with a diagnosis of a giant cell tumor which is very similar in clinical, radiological, and histological features to brown tumor. Therefore, we aim to share our experience of giant cell epulis as a presenting manifestation in PHPT patients in a tertiary care center in North India.
Bringhurst FR, Demay MB, Kronenberg HM. Bone and Mineral Metabolism in Health and Disease. In: Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J, (Eds). Harrison's Principles of Internal Medicine, 20e. New York, NY: McGraw-Hill Education; 2018. pp. 2909–2921.
Khalekar Y, Zope A, Brahmankar U, et al. Hyperparathyroidism in dentistry: Issues and challenges!! Indian J Endocrinol Metab 2016;20(4):581–582. DOI: 10.4103/2230-8210.183452.
Smith BR, Fowler CB, Svane TJ. Primary hyperparathyroidism presenting as a “peripheral” giant cell granuloma. J Oral Maxillofac Surg 1988;46(1):65–69. DOI: 10.1016/0278-2391(88)90303-5.
Parbatani R, Tinsley GF, Danford MH. Primary hyperparathyroidism presenting as a giant-cell epulis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85(3):282–284. DOI: 10.1016/s1079-2104(98) 90009-9.
Pattnaik N, Rajguru JP, Pattanaik SJ, et al. Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report. J Family Med Prim Care 2020;9(6):3142–3146. DOI: 10.4103/jfmpc.jfmpc_479_20.
Bodner L, Peist M, Gatot A, et al. Growth potential of peripheral giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;83(5):548–551. DOI: 10.1016/s1079-2104(97)90118-9.
Chuong R, Kaban LB, Kozakewich H, et al. Central giant cell lesions of the jaws: A clinicopathologic study. J Oral Maxillofac Surg 1986;44(9):708–713. DOI: 10.1016/0278-2391(86)90040-6.
Triantafillidou K, Zouloumis L, Karakinaris G, et al. Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature. Am J Otolaryngol 2006;27(4):281–286. DOI: 10.1016/j.amjoto.2005.11.004.
Giansanti JS, Waldron CA. Peripheral giant cell granuloma: Review of 720 cases. J Oral Surg 1969;27(10):787–791. PMID: 5258991.
Choi C, Terzian E, Schneider R, et al. Peripheral giant cell granuloma associated with hyperparathyroidism secondary to end-stage renal disease: A case report. J Oral Maxillofac Surg 2008;66(5):1063–1066. DOI: 10.1016/j.joms.2007.11.030.